Draw the major E2 reaction product formed when cis-1-chloro-2-ethylcyclohexane (shown below) reacts with hydroxide i…
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Question “Draw the major E2 reaction product formed when cis-1-chloro-2-ethylcyclohexane (shown below) reacts with hydroxide i…”
Draw the major E2 reaction product formed when
cis-1-chloro-2-ethylcyclohexane (shown below) reacts with hydroxide
ion in DMSO.
Answer
A bi-molecular elimination reaction, the E2 elimination reaction, is possible. This is a single-step elimination process that follows a coordinated mechanism. The intermediate state in an E2 elimination reaction is called transition state. The reaction rate depends on the base as well as the substrate. Therefore, the E2 elimination reaction can be called a bimolecular elimination reaction.
The base that was used to attract the acidic pron in the substrate is the basis of an alkene product in an E2 elimination reaction. A Hoffman alkene will be produced if a large, bulky base is used. If the base is not steric inhibited, then a highly substituted Alkene will be the product.
The given substrate is cis-1-chloro-2-ethylcyclohexane
Below is the structure of the substrate.
Below is the ring flip for the given substrate.
Given base is {\rm{O}}{{\rm{H}}^{\rm{ - }}}
The base attack on the given substrate cis-1-chloro-2-ethylcyclohexane is shown below.
Below is the result of removing the substrate.
Ans:
The complete reaction
Conclusion
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