Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note…
The following solution is suggested to handle the subject “Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note…“. Let’s keep an eye on the content below!
Question “Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note…”
Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note that some references may not break out each of these steps individually, but all steps should be ordered. There will be eight steps. First step His 57 catalyzes removal of H from Ser 195 hydroxyl. Ser 195’s nucleophilic O attacks carbonyl C of substrate. The portion (the C-terminal end) of original substrate with the new amino terminus diffuses away. His 57 donates H to Ser 195 0, leading to collapse of tetrahedral intermediate. Water donates H to His 57. Resulting OH attacks carbonyl of remaining substrate. His 57 donates H to N of scissile peptide bond, tetrahedral intermediate decomposes. The portion (N-terminal end) of original substrate with the new carboxylate terminus diffuses away. Last step
х Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note that some references may < Feedback out each of these steps individually, but all steps should be ordered. There will be eight steps. Step 3: After Ser 195 attacks the substrate, the substrate is cleaved. First step His 57 catalyzes removal of H from Ser 195 hydroxyl. Ser 195’s nucleophilic O attacks carbonyl C of substrate. The portion (the C-terminal end) of original substrate with the new amino terminus diffuses away. His 57 donates H to Ser 195 0, leading to collapse of tetrahedral intermediate. Water donates H to His 57. Resulting OH attacks carbonyl of remaining substrate. His 57 donates H to N of scissile peptide bond, tetrahedral intermediate decomposes. The portion (N-terminal end) of original substrate with the new carboxylate terminus diffuses away. Last step Answer Bank
Answer
Note: Data in numericals are indicated with an alphabet.
A—>1
B—>2
G—>3
C—>4
E—>5
F—>6
D—>7
I’ISL SCP His57 catalyzes the removal of H from Ser195 hydroxyl. Ser 195’s nucleophilic OH attacks carbonyl B of substrate. The C-terminal portion of the original substrate is replaced by the new amino terminus. His 57 donates H and Ser 195 0, causing the collapse of the tetrahedral intermediary. Water donates H for His 57. The OH attack carbonyl of the remaining substrate results in a reversal. His 57 contributes H to N of the scissile protein bond, and the tetrahedral intermediary decomposes. b o The N-terminal portion of the original substrate is replaced by the new carboxylate terminus.
Conclusion
Above is the solution for “Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note…“. We hope that you find a good answer and gain the knowledge about this topic of science.