For each of the sites specified in the following molecules, indicate whether the site is nucleophilic,…
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Question “For each of the sites specified in the following molecules, indicate whether the site is nucleophilic,…”
For each of the sites specified in the following
molecules, indicate whether the site is nucleophilic,
electrophilic, or neither by dragging the appropriate label to the
box pointing to the site.
Answer
It is possible to see the structure of different compounds marked with different sites. These sites can then be classified as neutral, nucleophilic, or electrophilic. First, determine which sites are electron rich or poor. Next, mark the nucleophilic sites as nucleophilic, and the electrophilic sites as electron-poor. A neutral site should be designated if it is neither high in electron density nor low in electron density.
The electron density of electrophilic sites is generally low. This means that they either have a positive charge or are attached to the electronegative group or atoms that reduce their electron density. They are atoms or compounds that have an affinity for electrons. Consider the following example:
The electron density of nucleophilic sites is generally high. This means that they either have a negative charge or are attached to electron donating group that increase the electron density. An electron rich site is also one that contains a single pair of atoms. The atoms or compounds that have an affinity for protons and positive charge are called nucleophilic. Consider the following example:
They are not attached to electron donating groups or electron withdrawing group, nor do they have positive or negative charges. They are therefore neither nucleophilic nor electrophilic. Consider the following compound, for example:
Below are the structures of the compounds that have electron-poor sites and a small amount of positive charge.
Below are the structures of the compounds that have electron rich sites and generate a small amount of negative charge.
As shown below, write the structure of the neutral site compound.
Ans:
The following shows the locations of the nucleophile and electrophile sites.
Conclusion
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